The study found that 0.8% of same-sex patients with high-risk sexual activity were diagnosed with Crohn’s disease, while only 0.49 heterosexual men who engaged in high-risk sexual activity had Crohn’s disease.
The research will enable the development of individualized, precision medicine for the management of inflammatory bowel disease in this underrepresented minority patient group.
According to a recent study by Case Western Reserve University and University Hospitals Cleveland Medical Center (UH), homosexual men are more than twice as likely as heterosexual males to develop inflammatory bowel disease (IBD) when both groups participate in high-risk sexual activity.
The study was recently published in the peer-reviewed medical journal Gut.
“To our knowledge, this is the first large population-based study to demonstrate a higher prevalence of IBD in men who engage in high-risk same-sex sexual activity,” said Emad Mansoor, lead study author and assistant professor at Case Western. Reserve School of Medicine and UH. “Our study is expected to open a new field of research into gastrointestinal inflammatory conditions.”
“Studying the cause of IBD in this underrepresented patient population compared to other patient groups,” said Fabio Cominelli, corresponding study author, professor at the School of Medicine and chief scientific officer at UH, “will allow us to further investigate the cause of the development of disease in patients with Crohn’s disease and ulcerative colitis and develop personalized precision medicine and treatment strategies, while reducing stigma.”
The importance of the study is emphasized by the fact that, according to Gallup, more than 7.1% of Americans identify as LGBTQIA+, up from 5.6% in 2020.
The findings
Between 2002 and 2022, the researchers analyzed self-reported data from individuals treated at 58 healthcare organizations in the United States. This may interest you : Chiefs LB Willie Gay suspended four games for violating the NFL’s personal conduct policy.
According to the data, 0.8% of individuals with a diagnosis of high-risk same-sex activity had Crohn’s disease, and 1.26% had ulcerative colitis. These results were compared to those of males who participate in high-risk heterosexual behavior, of whom 0.49% had Crohn’s disease and 0.52% had ulcerative colitis.
This study defined high-risk sexual activity as sexual contact without barrier protection and also having multiple sexual partners.
The team also further analyzed the data related to Crohn’s disease and found men who engaged in high-risk same-sex sexual activity were more likely to have perianal disease including perianal abscess, rectal abscess and stricture disease of the colon. or small intestine. Among those with severe manifestations of ulcerative colitis, men who engaged in high-risk same-sex sexual activity were more likely to undergo a partial colectomy.
The findings will be further evaluated by the team – including investigating the possible role of the gut microbiome – during a long-term study that allows researchers to track participants over time.
Continuing research with NIH funding
The team will continue their research to better understand if and how GLBTQIA+ individuals are more susceptible to gastrointestinal disorders through funding provided this year for the Cleveland Digestive Diseases Research Core Center (DDRCC). Read also : Karine Jean-Pierre to Be First and First Gay Gay White House Press Secretary.
The center recently received a $100,000 supplemental grant from the National Institutes of Health (NIH). It will allow the researchers to significantly increase the number of GLBTQIA+ patients included in the DDRCC’s biorepository, which collects plasma, tissue and stool samples, and gut microbiome analyses.
“This supplemental grant is in addition to our $1 million NIH grant that runs from 2020 to 2025,” Cominelli said. “We are in the process of opening a new clinic dedicated to LGBTQ+ patients with the goal of improving access to health care. Our goal is to improve patient access and develop new therapies for gastrointestinal conditions.”
Reference: “Epidemiology of inflammatory bowel disease in men with high-risk homosexual activity” by Emad Mansoor, Scott A Martin, Abe Perez, Vu Quang Nguyen, Jeffry A Katz, Shubham Gupta and Fabio Cominelli, 1 September 2022, Gut.DOI: 10.1136/ gutjnl-2022-328218
